RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-21a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
PCR; immunofluorescence etc.
Target
SPRY1
Pathway
MAPK SIGNALING PATHWAY
PubMed ID
Title
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
Year
2008
Function
"miR-21 levels are increased selectively in fibroblasts of the failing heart, augmenting ERK-MAP kinase activity through inhibition of sprouty homologue 1 (SPRY1). In vivo silencing of miR-21 by a specific antagomiR in a mouse pressure-overload-induced disease model reduces cardiac ERK-MAP kinase activity, inhibits interstitial fibrosis and attenuates cardiac dysfunction."